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Use the options on the right-hand side to filter this list of studies by different Patient Recruitment Centres and/or by study status (open/upcoming/closed).


    Study date: 29 September 2023

    Status: Open

    This Pan-European pilot study compares Decentralised Clinical Trial (DCT) and hybrid approaches to conventional clinical trial approaches in patients with type 2 diabetes treated with a long-lasting insulin, called Toujeo®.

    If you would like further information, contact: or who are running the study.


    Study date: 09 May 2023

    Status: Open

    The study, REDEFINE 3, is looking at a combination of two medicines. REDEFINE 3 is needed to help us understand how effective these two medicines are for reducing cardiovascular events, such as heart attacks and stroke. This study is funded and sponsored by Novo Nordisk. 

    This study is open at PRC: Bradford, PRC: Leicester, PRC: Exeter. And upcoming at PRC: Blackpool and PRC: Newcastle.

    To find out more about the REDEFINE-3 study, please visit or contact the team:


    Study date: 08 December 2022

    Status: Open

    The purpose of this study is to understand how people with heart failure are treated, especially with regards to a class of medications for heart failure called “renin-angiotensin-aldosterone system inhibitors (RAASi)”. The study compares the given therapy to the treatment recommendations in guidelines from major cardiovascular diseases associations.

    RAASi medications are known to have many benefits for heart failure patients. However, RAASi can also cause high blood potassium in some patients (hyperkalaemia), which can be a dangerous condition. The most common treatment for a high blood potassium is to decrease the dose of, or stop RAASi treatment, despite the overall benefits.

    This study will investigate the changes to the RAASi medications overall, and after an episode of high blood potassium in patients who have or who are at a high risk of developing hyperkalaemia. The study will also investigate whether patients treated with RAASi according to the treatment guideline recommendations can potentially benefit by living longer, improving the heart failure symptoms, avoiding hospitalisations and avoiding cardiovascular events. Another aim of this study is to evaluate RAASi treatment patterns and effectiveness of patiromer (a drug which reduces potassium levels in patients with hyperkalaemia) in a subgroup of patients who are already being treated with patiromer as part of their regular medical care.

    This study is non-interventional, which means you will not receive any medications or treatments as part of the study. You will continue to receive your regular medical care from your doctor. Taking part in the study involves completing an electronic questionnaire about your symptoms and your quality of life upon enrolment and every 6 months until the end of your time on the study. The questionnaire takes about 5 minutes to complete.

    To find out more, contact us on


    Study date: 08 December 2022

    Status: Open

    The purpose of this study is to find out whether the daily intake of a dietary supplement with specific galacto-oligosaccharides (GOS) can reduce the symptom severity of patients with irritable bowel syndrome (IBS). Galacto-oligosaccharides are made up of sugars that are found naturally in dairy products, beans and certain root vegetables.

    GOS are used as prebiotics. Prebiotics act as food for "good" bacteria in the intestine. The study is testing the assumption that the study product improves your immune function and can result in a favourable change in the gut microbiome (the healthy bacteria that reside in your intestines) composition by increasing the ''good'' gut bacteria. The study compares the effects of the study product (a specific GOS) with the effects of a placebo. A placebo is a substance that looks like the study product but has no active ingredient.

    If you take part in the study, you will randomly receive either the study product or the placebo to be taken once a day. You will be asked to visit the study site 3 times in 10 weeks, have 3 telephone calls with a member of the team, and complete questionnaires and diaries from home throughout the course of the study. A visit at the study site will take approximately 1 hour. You will receive compensation for travel and parking expenses incurred to attend the study visits.


    To find out more, contact us on


    Study date: 08 December 2022

    Status: Open

    This is a clinical trial for patients diagnosed with non-obstructive coronary artery disease. The purpose of this research study is to determine if the study treatment, called inclisiran, taken in addition to statin medication can safely and effectively reduce the total amount of plaque formed in the heart’s vessels. The study will also focus on understanding how your body reacts to the study treatment as well as identifying the patients who would most likely benefit from this treatment using biomarker analysis.

    If you take part in the study, you will either receive the study treatment or a placebo, both of which will be given as an injection. You will be in the study for about 24 months and, during that time, will need to have between 8-12 study visits (either in person at the study site, by telephone, and/or at home). During the first 9 months of the trial, you will need to have between 5-8 study visits (either at the study site, by telephone, and/or at your home), depending on the type of statin medication you are currently taking.

    This trial is open at PRC: Newcastle and upcoming at PRC: Exeter and PRC: Bradford.

    To find out more, contact us on

    Study of Lipoprotein(a) Levels in Patients with a History of Atherosclerotic Cardiovascular Disease (ASCVD)

    Study date: 17 November 2022

    Status: Closed

    The aim of this study is to learn more about Lipoprotein(a) values (a type of protein in the blood) in people with coronary heart disease (known as Atherosclerotic Cardiovascular Disease [ASCVD]).

    Lipoprotein(a) is a particle that carries cholesterol in the blood and is a known risk factor for cardiovascular disease. High levels of Lp(a)are directly associated with a higher risk of cardiovascular events such as heart attacks or aortic stenosis. Unlike other lipid risk factors that can be influenced by diet, exercise, or obesity, Lp(a) levels are inherited and stay stable from childhood. Until more recently, the role of Lp(a) was not well understood and therefore it was not routinely tested for. This study aims to collect data on Lp(a) in ASCVD patients to understand better the distribution of this risk in such patients. 

    This study is being done to identify the people with a history of myocardial infarction (heart attacks) and/or percutaneous coronary intervention that have an Lp(a) level of at least 90 mg/dL or 200 nmol/L.

    For this study, if your Lp(a) value is known, no additional tests or procedures are required beyond what your regular doctor would normally do as part of your routine medical care. If your Lp(a) value is unknown, you will have 1 visit to the study site for data collection and blood collection only.

    Reasonable out of pocket expenses incurred through participation in this study will be reimbursed, including travel.

    To find out more, contact us on or 0191 282 3655.

    AMGEN CVOT Trial

    Study date: 31 July 2022

    Status: Closed

    The purpose of this study is to characterise the distribution of lipoprotein(a) (Lp(a)) levels among participants with a history of Atherosclerotic Cardiovascular Diseases (ASCVD) as defined by their medical history and is 2-fold:
    - Evaluate the distribution of Lp(a) value in the overall participants with a documented history of ASCVD
    - Evaluate the distribution of Lp(a) value in participants with a documented history of ASCVD by demographics and regions.

    CLOUDS study

    Study date: 04 February 2022

    Status: Open

    CLOUDS Study - Cross-sectional investigation of burden of disease in newly operated stoma patients

    The purpose of this study is to better understand the impact of living with a stoma on people who have had an ileostomy, or a colostomy.

    • If you decide to take part, we will arrange a phone call to help you understand more about the study. We will explain in detail about what your participation involves, and you will be able to ask any questions you may have. You are welcome to bring a family member or a friend to this meeting. If you choose to participate in the investigation, we will then ask you to sign a consent form, in which you agree to participate in the study as described in this information sheet.
    • During the study you will be invited for a virtual meeting with a member of the research team who will ask you a series of questions about your experience of living with a stoma and some personal information.
    • Virtual calls: All meetings will be planned to be virtual using Microsoft Teams, Skype or Face Time, if technically possible. If a virtual visit is not possible, a face-to-face meeting will be scheduled, either at your home or at the hospital site.
    • You will also be asked to fill in two (2) surveys. The surveys will be sent to you via a link in an email or SMS (text). The first survey will ask you questions on your personal experience of living with a stoma. The second survey is sent out at the end of the study so that you can feed back your experience of taking part in research. This is a way of demonstrating that your contribution is valued, and to help improve the way research studies are designed and delivered, now and in the future.
    • We will ask you to keep information about the study confidential, meaning that you are welcome to discuss the trial with your loved ones and of course also your GP/stoma nurse if there should be a need for this, but we must ask you not to share information about the study in a larger forum, such as on social media.

    CORVIS (COPD) trial

    Study date: 11 January 2022

    Status: Closed

    Please note that the CORVIS trial is currently paused.

    The CORVIS trial is investigating the use of a new drug (inhaled via a handheld nebuliser to produce nitric oxide in the lungs) for treatment of infective exacerbations of COPD and bronchiectasis. Nitric oxide plays a key part in our body’s own defence against microbial infection in the lungs and has already been approved for use in the treatment of lung disease in neonates. In this study it will be used in addition to the usual treatment you would receive during an infective exacerbation, such as oral steroids and antibiotics.


    Study date: 03 November 2021

    Status: Open

    Pan-European prospective observational study of fremanezumab effectiveness in patients with chronic or episodic migraine in the Real-World: PEARL study

    This study is currently closed to recruitment and in follow-up.

    Fremanezumab is a humanized monoclonal antibody that selectively targets calcitonin gene-related peptide and is approved in Europe for migraine prevention in adults with ≥4 migraine days/month. The Pan-European Real Life (PEARL) study is a 24-month, prospective, observational study of fremanezumab in chronic or episodic migraine. End points include proportion of patients with ≥50% reduction in monthly migraine days during 6 months of treatment (primary); changes in monthly migraine days, disability scores and acute headache medication use; adherence and persistence; and effectiveness in patients switching from another calcitonin gene-related peptide pathway-targeting monoclonal antibody. PEARL is being conducted in approximately 100 centers in 11 European countries (estimated n = 1100). PEARL will generate important real-world data on effectiveness of fremanezumab and treatment patterns in patients with chronic migraine or episodic migraine.