The study will enroll up to 27,500 participants in order to demonstrate the efficacy of the active Ad26.RSV.preF-based study vaccine in the prevention of Reverse Transcription Polymerase Chain Reaction (RT-PCR) confirmed Respiratory Syncytial Virus (RSV)-mediated Lower Respiratory Tract Disease (LRTD) when compared to placebo in adults aged 60 years and above.

The purpose of this study is to evaluate the efficacy and safety of vericiguat in participants with chronic heart failure with reduced ejection fraction (HFrEF), specifically those with symptomatic chronic HFrEF who have not had a recent hospitalisation for heart failure or need for outpatient intravenous (IV) diuretics.

The purpose of this Phase III study is to evaluate the efficacy and safety of Tozorakimab (MEDI3506) Dose 1 and Dose 2 administered subcutaneously (SC) in adult participants with symptomatic COPD and history of = 2 moderate or = 1 severe exacerbation of COPD in the previous 12 months. Participants should be receiving optimised treatment with maintenance inhaled therapy (ICS/LABA/LAMA triple therapy, or dual therapy if triple is not indicated or contraindicated) at a stable dose for at least 3 months prior to enrolment.

CLOUDS Study - Cross-sectional investigation of burden of disease in newly operated stoma patients

The purpose of this study is to better understand the impact of living with a stoma on people who have had an ileostomy, or a colostomy.

• If you decide to take part, we will arrange a phone call to help you understand more about the study. We will explain in detail about what your participation involves, and you will be able to ask any questions you may have. You are welcome to bring a family member or a friend to this meeting. If you choose to participate in the investigation, we will then ask you to sign a consent form, in which you agree to participate in the study as described in this information sheet.

• During the study you will be invited for a virtual meeting with a member of the research team who will ask you a series of questions about your experience of living with a stoma and some personal information.

• Virtual calls: All meetings will be planned to be virtual using Microsoft Teams, Skype or Face Time, if technically possible. If a virtual visit is not possible, a face-to-face meeting will be scheduled, either at your home or at the hospital site.

• You will also be asked to fill in two (2) surveys. The surveys will be sent to you via a link in an email or SMS (text). The first survey will ask you questions on your personal experience of living with a stoma. The second survey is sent out at the end of the study so that you can feed back your experience of taking part in research. This is a way of demonstrating that your contribution is valued, and to help improve the way research studies are designed and delivered, now and in the future.

• We will ask you to keep information about the study confidential, meaning that you are welcome to discuss the trial with your loved ones and of course also your GP/stoma nurse if there should be a need for this, but we must ask you not to share information about the study in a larger forum, such as on social media.

Please note that the CORVIS trial is currently paused.

The CORVIS trial is investigating the use of a new drug (inhaled via a handheld nebuliser to produce nitric oxide in the lungs) for treatment of infective exacerbations of COPD and bronchiectasis. Nitric oxide plays a key part in our body’s own defence against microbial infection in the lungs and has already been approved for use in the treatment of lung disease in neonates. In this study it will be used in addition to the usual treatment you would receive during an infective exacerbation, such as oral steroids and antibiotics.

This phase 3 randomised study will compare the efficacy of teclistamab-daratumumab (Tec-Dara) with daratumumab subcutaneously (SC) in combination with pomalidomide and dexamethasone (DPd) or daratumumab SC in combination with bortezomib and dexamethasone (DVd) in participants with relapsed or refractory multiple myeloma.

The study will be conducted in 3 phases: Screening Phase, Treatment Phase, and Follow-up Phase. Participants will be treated until disease progression, unacceptable toxicity , or other reasons to discontinue the study.

BESRA is a national, multi-center, prospective, observational study to assess the effectiveness of brolucizumab intravitreal injections in patients with nAMD treated in the UK.

A phase IV, open-label, prospective, multi-centre cohort study in patients with severe eosinophilic asthma (Global Initiative for Asthma [GINA] steps 4 and 5 classification of asthma severity) who will be treated with benralizumab injections. The study is exploratory and will assess deteriorations in asthma control (exacerbations) to characterise the clinical severity of each exacerbation and the airway and systemic inflammatory phenotype associated with these events. Clinical assessment and management of each exacerbation will be in line with standard clinical guidelines. 150 participants will be recruited and receive treatment for either 56 or 80 weeks.

The purpose of the study is to evaluate the efficacy and safety of two doses of CHF6001 (Tanimilast), as add-on to maintenance triple therapy in the target patient population. (PILASTER)

The purpose of this study is to obtain information on the efficacy (effectiveness) and the safety of two doses of CHF6001, a product developed by Chiesi Farmaceutici S.p.A. for the treatment of Chronic Obstructive Pulmonary Disease (COPD). (PILAR)