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The West Midlands Research Response to COVID19

 

Contents

Our Response To the COVID19 Pandemic 

Working with partners across the health and care system, NIHR is leading, enabling and delivering world-class COVID-19 research, a key element of the Government’s overall response to the pandemic. Find out more on the NIHR website.

On behalf of the Department of Health and Social Care, the NIHR is funding and helping to deliver a range of rapid response research to better understand and tackle COVID-19, including research into vaccines, treatments and diagnostic tests, and real-time collection of samples and data from people undergoing treatment in hospitals. We are doing this in close cooperation with Public Health England, UK Research & Innovation, the Health Research Authority and others. The Clinical Research Network is helping to set up and run these studies in every region of England.

Read our latest COVID-19 Staff Blog below.

Care Home Nursing During Covid-19 - Clare's Story

What COVID19 Clinical Trials are Open in the West Midlands?  See the list below (Updated weekly)

Non-Commercial COVID-19 Studies Open in the West Midlands  - Last updated: 20 May 2020 (alphabetical by name)

 

Study Name

Summary/Description

Study Website (where available)

Coronavirus Infection in Immunosuppressed Children

This is an observational study to investigate the impact of Covid-19 on children who are immunosuppressed.  The study is designed to allow a parent of immunosuppressed children and the children and teenagers to self-record their experiences each week via a website link. 

N/A

GenOMICC

This aim of this study is to

  • identify genetic variants within patients which are associated with susceptibility to and mortality from life-threatening infection

  • Prioritise therapeutics targets which modulate the patient’s response to the infection

https://genomicc.org/

ISARIC

A UK-wide consortium of doctors and scientists committed to answering urgent questions about COVID-19 :

  • How long are people infectious, and what body fluids are infectious?

  • What puts people at higher risk of severe illness?

  • What is the best way to diagnose the disease?

  • Who should we treat early with drugs, and which drugs cause harm?

  • Does the immune system in some patients do more harm than good?

  • What other infections(such as pneumonia or flu) happen at the same time?

https://isaric4c.net/

Neo-Natal Complications of COVID-19

This is a national surveillance programme using the standard British Paediatric Surveillance Unit (BPSU) approach. This study will run alongside and be cross-linked with the maternal surveillance study run through the United Kingdom Obstetric Surveillance System (UKOSS - see below) which is already in progress. Observational study- will collect information about newborn babies who have coronavirus or who are born to mothers who have.

 N/A

PANCOVID

The aim of this study is to understand the natural history of COVID-19 in pregnancy, in order to guide treatment and prevention during the outbreak.

https://pan-covid.org/

PRIEST

The aim of this study is to optimise the triage of people using the emergency care system (111 and 999 calls, ambulance conveyance, or hospital emergency department) with suspected respiratory infections during a pandemic and identify the most accurate triage method for predicting severe illness among patients attending the emergency department with suspected pandemic influenza respiratory infection. 

https://www.sheffield.ac.uk/scharr/sections/hsr/cure/priestpages/priest

PRINCIPLE

Aims to find out whether selected treatments given to people at higher risk of becoming more ill when they are infected with COVID-19 can help reduce the need for hospitalisation and the length of stay required, helping people recover quicker and with fewer complications. The trial is recruiting participants through GP practices across the UK. 

https://www.phctrials.ox.ac.uk/principle-trial

REALIST

The REALIST trial plans to test if treatment with a preparation of MSCs, called REALIST ORBCEL-C, can improve outcomes in patients with Acute Respiratory Distress Syndrome

https://www.hra.nhs.uk/covid-19-research/approved-covid-19-research/227090/

RECOVERY

Aims to identify treatments that may be beneficial for adults hospitalised with confirmed COVID-19. *Open to children from 9/5/20 

https://www.recoverytrial.net/

RECOVERY- Respiratory Support

Compare the effectiveness of three ventilation methods;

  • Continuous positive airway pressure (CPAP): this treatment applies mild to high air pressure on a continuous basis through a tightly fitted face mask. It keeps the airways continuously open in people who are able to breathe normally on their own, but need help keeping their airway clear.

  • High flow nasal oxygen (HFNO): this is a way of giving humidified (moistened) and warmed oxygen through tubes into the nose. The oxygen is delivered very quickly to help patients who have low oxygen levels and find breathing on their own difficult.

  • Standard care: standard treatment will involve oxygen delivered via a normal face mask or tubes in the nose.

https://warwick.ac.uk/fac/sci/med/research/ctu/trials/recovery-rs

REMAP-CAP

This is an international randomised controlled trial, looking at the effect a number of different drugs has on those with significant community-acquired pneumonia.   It is targeted towards those who are in ICU

https://www.remapcap.org/

 STOP COVID-19

The overall objective of the study is to evaluate the clinical efficacy of Brensocatib compared to placebo on top of standard care in adult patients hospitalised with COVID-19.

 N/A

UKOSS

COVID-19 in Pregnancy

https://www.npeu.ox.ac.uk/ukoss/current-surveillance/covid-19-in-pregnancy