The West Midlands Research Response to COVID19
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Our Response To the COVID19 Pandemic
Working with partners across the health and care system, NIHR is leading, enabling and delivering world-class COVID-19 research, a key element of the Government’s overall response to the pandemic. Find out more on the NIHR website.
On behalf of the Department of Health and Social Care, the NIHR is funding and helping to deliver a range of rapid response research to better understand and tackle COVID-19, including research into vaccines, treatments and diagnostic tests, and real-time collection of samples and data from people undergoing treatment in hospitals. We are doing this in close cooperation with Public Health England, UK Research & Innovation, the Health Research Authority and others. The Clinical Research Network is helping to set up and run these studies in every region of England.
Read our latest COVID-19 Blogs, Case Studies and Patient Stories below:
Reaping The Rewards of Research - Kirsty's Story
Delivering Moonshot - Pam's Story
Why I'm Helping Find a Vaccine for Covid-19 - Claire's Story
Taking Part In Dementia Research During a Pandemic - Phil & Audrey's Story
Lifting the Cloak of Invisibility - Heather's Story
Supporting Families During COVID-19 - Mary-Anne's Story
Why I'm Taking Part in a COVID-19 Vaccine Study - Josh's Story
Antibody Angels - Jane's Story
Donating a Record Amount of Plasma - Steve's Story
COVID-19 - Working Together for RECOVERY
No Going Back - How a Mental Health & Community Trust has Supported the COVID-19 Research Effort
Giving Something Back - Kerry's Story
Care Home Nursing During Covid-19 - Clare's Story
Why Clinical Research Is More Important Now than Ever - Dr Chris Green
Our Experience as COVID-19 Medical Student Volunteers
Redeployment During a Pandemic - Fawn's Story
What COVID19 Clinical Trials are Open in the West Midlands? See the list below.
Non-Commercial COVID-19 Studies Open in the West Midlands - Last updated: 8 March 2021 (alphabetical by name)
Study Name |
Summary/Description |
Study Website (where available)/Online info |
ACCORD 2 |
A Multicentre, Seamless, Phase 2 Adaptive Randomisation Platform Study to Assess the Efficacy and Safety of Multiple Candidate Agents for the Treatment of COVID-19 in Hospitalised Patients. Stage 1: To evaluate the efficacy of candidate agents as add on therapies to Standard of Care (SoC) in patients |
https://www.uhs.nhs.uk/ClinicalResearchinSouthampton/Research/COVID-19/ACCORD/ACCORD.aspx |
ADAPT-SEPSIS |
BiomArker-guided Duration of Antibiotic treatment in hospitalised PaTients with suspected Sepsis. This is an existing study within the NIHR CRN Portfolio and a UK-wide multi-centre randomised controlled trial, which aims to determine whether treatment protocols based on monitoring daily CRP (C-reactive protein) or PCT (procalcitonin) safely allow a reduction in duration of antibiotic therapy in hospitalised adult patients with suspected sepsis. The addition of recruitment of COVID-19 patients to ADAPT-Sepsis will address an area of unmet research need. |
https://warwick.ac.uk/fac/sci/med/research/ctu/trials/adaptsepsis
|
CATALYST |
A Birmingham-led drugs trial testing potential treatments for patients in hospital with COVID-19 |
https://www.research.uhb.nhs.uk/major-covid-19-drugs-trial-begins-in-birmingham/ |
COG-UK HOCI study |
Hospitals are recognised to be a major risk for the spread of infections despite the availability of protective measures. Under normal circumstances, staff may acquire and transmit infections, but the health impact of within hospital infection is greatest in vulnerable patients. For the novel coronoavirus that causes COVID-19, like recent outbreaks such as the SARS and Ebola virus, the risk of within hospital spread of infection presents an additional, significant health risk to healthcare workers. Infection Prevention and Control (IPC) teams within hospitals engage in practices that minimise the number of infections acquired within hospital. This includes surveillance of infection spread, and proactively leading on training to clinical and other hospital teams. There is now good evidence that genome sequencing of epidemic viruses such as that which causes COVID-19, together with standard IPC, more effectively reduces within hospital infection rates and may help identify the routes of transmission, than just existing IPC practice. It is proposed to evaluate the benefit of genome sequencing in this context, and whether rapid (24-48h) turnaround on the data to IPC teams has an impact on that level of benefit. The study team will ask participating NHS hospitals to collect IPC information as per usual practice for a short time to establish data for comparison. Where patients are confirmed to have a COVID-19 infection thought to have been transmitted within hospital, their samples will be sequenced with data fed back to hospital teams during the intervention phase. A final phase without the intervention may take place for additional information on standard IPC practice when the COVID-19 outbreak is at a low level nationwide. |
https://www.cogconsortium.uk/studies/
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COVID-HEART: Demographic, multi-morbidity and genetic impact on myocardial involvement and its recovery from COVID-19: a UK national study |
The aims of this study are to characterise the prevalence and extent of myocardial involvement from COVID-19 infection, and to assess recovery status at 6 months. Additionally this study aims to understand the impact of this on patient quality of life and functional capacity for a UK population. |
N/A |
COVID-19 National DiagnOstic Research and Evaluation Platform (CONDOR) FALCON |
This is a phase 2/3, participant-blinded individually randomised controlled trial in adults and healthy children in the UK, administering either a single dose or two doses of ChAdOx1 nCoV-19 vaccine or a licensed MenACWY vaccine via IM injection. Adult volunteers aged at least 18 years, and healthy children aged 5–12 years (inclusive) will be recruited into this study. |
https://www.condor-platform.org/condor_workstreams/falcon
|
GenOMICC |
This aim of this study is to
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ISARIC |
A UK-wide consortium of doctors and scientists committed to answering urgent questions about COVID-19 :
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MERMAIDS |
This is a phase 2/3, participant-blinded individually randomised controlled trial in adults and healthy children in the UK, administering either a single dose or two doses of ChAdOx1 nCoV-19 vaccine or a licensed MenACWY vaccine via IM injection. Adult volunteers aged at least 18 years, and healthy children aged 5–12 years (inclusive) will be recruited into this study. Advertisements will be used to recruit volunteers. |
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Neo-Natal Complications of COVID-19 |
This is a national surveillance programme using the standard British Paediatric Surveillance Unit (BPSU) approach. This study will run alongside and be cross-linked with the maternal surveillance study run through the United Kingdom Obstetric Surveillance System (UKOSS - see below) which is already in progress. Observational study- will collect information about newborn babies who have coronavirus or who are born to mothers who have. |
N/A |
PANCOVID |
The aim of this study is to understand the natural history of COVID-19 in pregnancy, in order to guide treatment and prevention during the outbreak. |
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(PHOSP-COVID) Post-hospitalisation COVID-19 study: a national consortium to understand and improve long-term health outcomes |
The COVID-19 pandemic has had a major impact on the UK’s health, social care and economy. The long-term sequelae of COVID-19 after discharge from hospital in both those with and without comorbidities are unknown. A comprehensive patient-centred holistic study is required to determine the chronic health and health economic sequelae of COVID-19 infection in post-hospitalisation survivors. This will define demographic, clinical and molecular biomarkers of the susceptibility and inform our understanding of the impact of interventions during the acute illness. These insights will guide consequent in-depth studies to inform precision medicine in at risk groups by directing new clinical trials and care for current and future post-COVID-19 patients. |
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PRINCIPLE |
Aims to find out whether selected treatments given to people at higher risk of becoming more ill when they are infected with COVID-19 can help reduce the need for hospitalisation and the length of stay required, helping people recover quicker and with fewer complications. The trial is recruiting participants through GP practices across the UK. |
|
REALIST |
The REALIST trial plans to test if treatment with a preparation of MSCs, called REALIST ORBCEL-C, can improve outcomes in patients with Acute Respiratory Distress Syndrome |
https://www.hra.nhs.uk/covid-19-research/approved-covid-19-research/227090/ |
RECOVERY |
Aims to identify treatments that may be beneficial for adults hospitalised with confirmed COVID-19. *Open to children from 9/5/20 |
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RECOVERY- Respiratory Support |
Compare the effectiveness of three ventilation methods;
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https://warwick.ac.uk/fac/sci/med/research/ctu/trials/recovery-rs |
REMAP-CAP |
This is an international randomised controlled trial, looking at the effect a number of different drugs has on those with significant community-acquired pneumonia. It is targeted towards those who are in ICU |
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SIREN |
This study aims to find out whether healthcare workers who have evidence of prior COVID-19, detected by antibody assays (positive antibody tests), compared to those who do not have evidence of infection (negative antibody tests) are protected from future episodes of infection. |
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TACTIC |
TACTIC plans to recruit patients at an early stage in the disease course, aiming for a timepoint where the patient is experiencing early infection and starting to show mild pulmonary complications. The purpose is to prevent organ damage and reduce the need to transfer to ICU and ventilation. T |
https://www.nihr.ac.uk/news/tactic-new-national-trial-launched-to-find-covid-19-treatment/24851 |
UKOSS |
COVID-19 in Pregnancy |
https://www.npeu.ox.ac.uk/ukoss/current-surveillance/covid-19-in-pregnancy |
UK REACH |
United Kingdom Research Study into Ethnicity And COVID-19 outcomes in Healthcare workers. The aim of this study is to identify if, how, and why, ethnicity affects COVID-19 diagnosis and clinical outcomes in Healthcare Workers, and the impact of COVID-19 on the physical and mental health of Black, Asian and Minority Ethnic Healthcare Workers. |