CRN East Midlands COVID-19 Studies
CRN East Midlands is working with partners across the region to deliver Urgent Public Health research studies into COVID-19. These studies are designed to enable us to better understand and tackle COVID-19, including aiding with the development of treatments and a vaccine.
You can find out more about each of the COVID-19 research studies currently in operation across the East Midlands below:
This new, national clinical trial initiative is seeking to accelerate the development of new drugs for patients hospitalised with COVID-19. If positive early results are seen, these drugs will advance rapidly into large-scale clinical trials.
This study is seeking to find out whether the duration of antibiotic treatment given to patients with sepsis can be safely reduced following the close monitoring of biomarkers.
A Phase 3 COVID-19 Vaccine Study
This study is trialing a vaccine developed by Janssen-Cilag LTD.
A trial to evaluate SARS-CoV-2 Recombinant Nanoparticle vaccine
This study trialing a vaccine developed by Novavax Inc.
This study is exploring whether an intervention delivered over the phone by trained support workers can prevent or improve depression symptoms during lockdown, and whether it is acceptable to older adults and support workers.
This study is aiming to understand the impact of inflammatory bowel disease treatments and physical distancing strategies on COVID-19 through the use of serology testing.
This study is investigating whether chloroquine or hydroxychloroquine are effective in preventing COVID-19, enrolling front line workers and staff who have close contact with COVID-19 patients.
This study is evaluating the diagnostic accuracy of IVDs (in vitro diagnostic devices) for COVID-19 infection and monitoring the immune response.
This study is aiming to determine whether specific genes can cause susceptibility to COVID-19, which could help to determine and prioritise treatments used in response to the pandemic.
Investigating a vaccine against COVID-19 (COV002)
This study is investigating the effectiveness of a new vaccine that has been developed for COVID-19.
This study is investigating for how long people are infectious with COVID-19, and what puts people at higher risk of infection.
The aim of this study is to understand why some people become much more ill than others when they have acute respiratory infections, and will include the analysis of blood samples to determine different risk factors.
Neonatal Complications of Coronavirus Disease
This study is analysing how COVID-19 affects babies, including symptoms and prevalence.
This study is exploring how the COVID-19 pandemic is disrupting the work of NHS staff in order to identify how best to support acute hospital staff during pandemics.
This study is collecting data about the impact of COVID-19 during pregnancy to help better understand the disease and to guide improvements in patient care for pregnant women.
This study is conducting assessments of patients who have been hospitalised with COVID-19 to understand the impact that the virus has on longer term health outcomes.
This study, which is operating through GP practices, is seeking to determine whether existing treatments could be used to help people with COVID-19 symptoms and prevent them from needing to be hospitalised.
This study is assessing the accuracy of different rapid tests for COVID-19 for patients in the community, working across GP surgeries and COVID-19 testing sites.
This study, which takes place in hospitals, is exploring whether a range of possible treatments are more effective in helping COVID-19 patients recover than the usual standard of hospital care, which all patients receive.
RECOVERY RS (Respiratory Support)
This study is designed to compare the effectiveness of three ventilation methods for COVID-19 patients, exploring whether they help patients recover more quickly than those receiving standard hospital care.
This study is targeted at patients in intensive care units, and is looking at the effect a number of drugs have on patients with significant community-acquired pneumonia.
This study is seeking to determine whether healthcare workers who have evidence of prior COVID-19 infection (determined by a positive antibody test) are protected from future episodes.
This study is seeking to determine whether a new drug, Brensocatib, can help people with COVID-19.
UKOSS: Pandemic Influenza in Pregnancy
This study is seeking to understand the impact of COVID-19 on pregnancy, including how treatment of the disease affects outcomes for mother and infant.
This study will use existing data from healthcare records to build a comprehensive picture of the impact of COVID-19 on the physical and mental well-being of ethnic minority healthcare workers.
This study aims to understand how COVID-19 spreads and how to stop it, by asking people to undertake antibody tests and to keep diaries of illness and symptoms.
This study is exploring how many care home staff and residents have been infected with COVID-19 to inform decisions about the best approach to testing in the future.
What's the Story
This study is seeking to determine how many children and young adults in different regions of England have had COVID-19 by looking for specific antibodies in a single blood sample.